Order Information
Catalog# Size Price
P20405 100μl $240
 
Specification
Entrez Gene ID 174
Aliases alpha-fetoprotein; FETA; HPAFP
Clone# 6E6
MW 69kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human
Immunogen Purified recombinant fragment of human AFP expressed in E. Coli.
Formulation Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
 
Application
WB 1/500 - 1/2000
IHC N/A
ICC N/A
FCM N/A
ELISA Propose dilution 1/10000
Description
AFP (alpha-fetoprotein), a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
 
References
1. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7160-4.
2. Pediatr Hematol Oncol. 2001 Dec;18(8):509-18.
3. Tumour Biol. 2002 Jul-Aug;23(4):202-11.