Order Information
Catalog# Size Price
P30312 0.1mg/ml $310
 
Specification
Entrez Gene ID 1543
Aliases AHH; AHRR; CP11; CYP1; P1-450; P450-C; P450DX
Clone# 6G5
MW 58kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human
Immunogen Purified recombinant fragment of human CYP1A1 expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer
 
Application
WB 1/500 - 1/2000
IHC 1/200 - 1/1000
ICC N/A
FCM N/A
ELISA Propose dilution 1/10000
Description
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
 
References
1. Cancer Res. 2009 Apr 1;69(7):2956-65.
2. Drug Metab Lett. 2009 Jan;3(1):18-27.