Order Information
Catalog# Size Price 
P30119 100μl $280
 
Specification
Entrez Gene ID 5460
Aliases OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; MGC22487; POU5F1
Clone# 7E7
MW 45kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human
Immunogen Synthesized peptide derived from internal of human Oct4.
Formulation Ascitic fluid containing 0.03% sodium azide.
 
Application
WB 1/500 - 1/2000
IHC N/A
ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA Propose dilution 1/10000
Description
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. (provided by RefSeq).Tissue specificity: Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues.
 
References
1. Stem Cells. 2010 May;28(5):885-93.
2. Mol Med. 2010 Jul-Aug;16(7-8):247-53.
3. Med Sci (Paris). 2010 Apr;26(4):411-6.