Order Information
Catalog# Size Price
P20374 100μl $280
 
Specification
Entrez Gene ID 10381
Aliases tubulin, beta 3; MC1R; TUBB4
Clone# 2E9
MW 50kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human
Immunogen Purified recombinant fragment of human TUBB3 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
 
Application
WB 1/500 - 1/2000
IHC N/A
ICC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA Propose dilution 1/10000
Description
Tubulin, beta 3, also known as TUBB3. Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non exchangeable site on the alpha-chain. Tubulin is a highly conserved protein with a molecular weight of ~50 kD. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. The two main tubulin isoforms, α- and β-tubulin, are usually products of separate genes. The β-tubulin family includes six expressed genes that produce the polypeptide isoforms known as Classes I through VI, each of which have a distinct pattern of expression. Class III β-tubulin is found in neurons and mammalian testis cells and is widely used as a neuronal marker in developmental neurobiology, neoplasia, and stem cell research. Class III β-tubulin expression in neuronal and neuroblastic tumors is differentiation dependent, and its expression in certain non-neuronal neoplasms has been associated with poor prognosis and/or resistance to chemotherapy.
 
References
1. Histopathology. 2007 Jun;50(7):949-52.
2. Neurochem Res. 2007 Aug;32(8):1387-98.
3. Exp Eye Res. 1995 Apr;60(4):385-400.