Order Information
Catalog# Size Price
P30209 100μl $310
 
Specification
Entrez Gene ID 4609
Aliases MRTL; c-Myc; bHLHe39
Clone# 7E10
MW 49kDa
Host/Isotype Mouse IgG1
Storage 4℃; -20℃ for long term storage
Species Reactivity Human
Immunogen Purified recombinant fragment of human MYC expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
 
Application
WB 1/500 - 1/2000
IHC N/A
ICC N/A
FCM N/A
ELISA Propose dilution 1/10000
Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided by RefSeq).
 
References
1. Mol Cell. 2009 Sep 11;35(5):610-25.
2. Clin Immunol. 2009 Dec;133(3):324-32.