Order Information
Catalog# | Size | Price |
P30209 | 100μl | $310 |
Specification
Entrez Gene ID | 4609 |
Aliases | MRTL; c-Myc; bHLHe39 |
Clone# | 7E10 |
MW | 49kDa |
Host/Isotype | Mouse IgG1 |
Storage | 4℃; -20℃ for long term storage |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human MYC expressed in E. Coli. |
Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application
WB | 1/500 - 1/2000 |
IHC | N/A |
ICC | N/A |
FCM | N/A |
ELISA | Propose dilution 1/10000 |
Description
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. (provided by RefSeq). |
References
1. Mol Cell. 2009 Sep 11;35(5):610-25. |
2. Clin Immunol. 2009 Dec;133(3):324-32. |