Description:

Lentivirus vectors based on the human immunodeficiency virus-1 (HIV-1) have become a promising tool for gene transfer studies. Lentiviral vectors packaged as lentiviral particles are one of the most efficient tools to deliver exogenous genes into virtually any type of mammalian cells both in vitro and in vivo, and their use is now commonplace in academic and industrial laboratories for both research and clinical gene therapy applications. The advantageous feature of lentiviral vectors is their ability for gene transfer and integration into both dividing and non-dividing cells, with low immune response and toxicity in vivo. These viruses also integrate stably into the host genome, enabling long-term transgene expression. Hence, the number of applications to introduce genes using lentiviruses for in vitro systems, animal models and in clinical trials has been increasing worldwide.

Our lentiviral vectors have been designed with third generation system standards for increased researcher safety. pLenti-CMV-luciferase-EF1-NeoR Lentiviral Reporter Vector contains the firefly luciferase gene driven by a CMV promoter and NeoR driven by an EF1a promoter. Luciferase is widely used as a reporter for studying gene regulation and function, and for pharmaceutical screening. The EF1-NeoR cassette permits G418 selection.

Specifications: