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HEK293-hACE2 Cell Line

Catalog# Unit Unit Price (USD) Actions
AL01 1 x106 cells/vial $3600 Add to Cart
Highlights:

This HEK293-hACE2 cell line is derived from HEK293 cells by transducing lentivirus particles encoding human angiotensin I converting enzyme 2 (ACE2) gene. The cell line stably expresses hACE2 and is an excellent cell resource for in vitro drug screening and characterization against coronaviruses including SARS-CoV-2 virus.

  • Stable express of human ACE2
  • Ready-to-use in cell-based assays such as screening for inhibitors against human ACE2
  • Ideal tool for antibody neutralization assay against SAR-CoV-2 virus

Academic customers, please contact us for coupon code. 

Description:

Human angiotensin-converting enzyme 2 (hACE2) is an enzyme on the cell membranes of cell in multiple organs such as lungs, heart, kidney, arteries and intestines. It serves as a critical entry receptor for many coronaviruses, including SARS-CoV, MERS-CoV, as well as SARS-CoV-2 that causes COVID-19, a pandemic disease.

This HEK293-hACE2 cell line is derived from HEK293 cells by transducing lentivirus particles encoding human ACE2 gene. The cell line stably expresses hACE2 and is an excellent cell resource for in vitro drug screening and characterization against coronaviruses includingSARS-CoV-2 virus.

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Figure 1. Infection of HEK293-hACE2 cells by pseudotyped GFP SARS-CoV-2 virus (Cat# SV01). GFP expression was observed on infected hACE2 cells 48 hours post transduction, wherease no GFP expression was detected in HEK293 wild type (WT) cells.
images/Desc_Images/AL01_2.png
Figure 1. Infection of HEK293-hACE2 cells by pseudotyped GFP SARS-CoV-2 virus (Cat# SV01). GFP expression was observed on infected hACE2 cells 48 hours post transduction, wherease no GFP expression was detected in HEK293 wild type (WT) cells.
Specifications:
Product Name HEK293-hACE2 Cell Line
Shipping Condition

Dry Ice - Overnight Shipping

Storage and Stability

Store in vapor phase of liquid nitrogen immediately upon receipt. This product is stable for 6 months when stored as directed.

Quality Control

Each vial contains about 1 x 106 cells with >95% viability before freezing. Each lot of cells is tested for infectivity of spike (SARS-CoV-2) pseudotyped GFP lentivirus, growth and viability following recovery from cryopreservation, and free of mycoplasma and competent lentivirus as well.

Restricted Use

For Research Use Only. Not for use in diagnostic or therapeutic procedures.