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All Products Gene Editing Knockout gRNA Vectors
Knockout gRNA Vectors
Plasmid-based vectors co-expressing Cas9 (CBh promoter) and pre-cloned, validated gRNAs (U6 promoter) for high-efficiency genome editing. Selectable after transfection and usable individually or in pairs for streamlined knockout experiments.
Validated Performance
- Experimentally validated for high cutting efficiency
- Optimized specificity for reliable genome editing
Flexible Applications
- Generate small deletions causing frameshift mutations
- gRNAs used individually or paired
All in one design
- Co-expresses SpCas9 protein and pre-cloned gRNA
- Includes selectable marker for transfection-based selection
Mechanism
Pre-validated gRNAs with high cutting efficiency and specificity are cloned into all-in-one plasmid vectors. The U6 promoter drives gRNA expression, while the CBh promoter controls SpCas9 and a selectable marker (e.g., puromycin). Single or paired gRNAs induce indels, potentially causing frameshifts, premature termination of the coding sequence, or production of nonfunctional proteins.
Application
Gene Knockout & Functional Studies
- Generating frameshift knockouts: introduces insertions or deletions that disrupt the reading frame, effectively inactivating the gene.
- Functional genomics: study gene function, regulatory networks, and molecular pathways.
Biomedical Research & Disease Modeling
- Investigation of genetic diseases and disorders.
- Development of cellular or animal models for understanding disease mechanisms.
- Screening for potential therapeutic targets.
Biotechnology & Synthetic Biology
- Creation or optimization of biotechnological products in agriculture, industry, or synthetic biology.
- Engineering of microbial, plant, or mammalian systems for desired traits.
Drug Discovery & Therapeutic Development
- Validation of drug targets by gene knockout.
- Testing gene function in response to small molecules or biologics.
- Exploration of novel treatment strategies through targeted gene disruption.
Product List
| ID | Catalog# | Name | Unit | Unit Price (USD) | Actions |
|---|---|---|---|---|---|
| 247 | G001a | CD123-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 248 | G001b | CD123-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 249 | G001c | CD123-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 250 | G002a | FAM171A2-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 251 | G002b | FAM171A2-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 252 | G002c | FAM171A2-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 253 | G003a | FKBP5-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 254 | G003b | FKBP5-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 255 | G003c | FKBP5-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 256 | G004a | LDLR-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 257 | G004b | LDLR-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 258 | G005a | LLGL1-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 259 | G005b | LLGL1-KO gRNA5 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 260 | G005c | LLGL1-KO gRNA6 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 261 | G005d | LLGL1-KO gRNA14 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 262 | G006a | Neo1-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 263 | G006b | Neo1-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 264 | G006c | Neo1-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 265 | G007a | PLGC2-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 266 | G007b | PLGC2-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 268 | G008a | PLN-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 267 | G007c | PLGC2-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 269 | G008b | PLN-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 270 | G008c | PLN-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 271 | G009a | RABGGTB-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 272 | G009b | RABGGTB-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 273 | G009c | RABGGTB-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 274 | G009d | RABGGTB-KO gRNA4 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 275 | G600a | Mcu1-KO gRNA1 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 276 | G600b | Mcu1-KO gRNA2 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 277 | G600c | Mcu1-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 384 | G004c | LDLR-KO gRNA3 | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
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