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All Products Gene Editing gRNA Expression Vectors
gRNA Expression Vectors
Lentiviral vectors with a U6 promoter for cloning user-defined gRNAs. Available with selectable markers, these vectors are fully compatible with CRISPRi and CRISPRa systems for precise gene regulation.
CRISPR-a
- dCas9-VPR Compatibility
- Transcriptional activation
- Gene upregulation
CRISPR-i
- dCAS9-KRAB Compatibility
- Transcriptional repression
- Gene silencing
Selection markers
- Blasticidin
- Puromycin
- Neomycin
Mechanism
The catalytically inactive dCas9 protein acts as a programmable DNA-binding platform. When fused to transcriptional regulators—KRAB for repression or VPR for activation—dCas9 enables precise, guide RNA–directed control of gene expression.
Application
Genome wide gene editing, activation or inhibition
Targeted Gene Regulation
- Promoter-specific control: selectively upregulate or downregulate genes via guide RNA targeting.
- Precise transcriptional modulation without altering the DNA sequence.
Stable and Long-Term Modulation
- Lentiviral delivery enables genomic integration for sustained gene activation or repression.
- Generation of stable dCas9-VPR or dCas9-KRAB cell lines ensures reproducible results.
Flexible, Multi-Organism Use
- Compatible with a wide range of mammalian cells and other model systems.
- Supports diverse research applications from functional biology to pathway analysis.
Efficient, Scalable Workflows
- Dual-vector co-transduction: simultaneous delivery of dCas9 and gRNA for higher efficiency.
- Multiplexing capability: simultaneous regulation of multiple genes or pathways.
- Functional genomic screens and drug target validation using CRISPRa or CRISPRi libraries.
Product List
| ID | Catalog# | Name | Unit | Unit Price (USD) | Actions |
|---|---|---|---|---|---|
| 289 | CG101 | pLV-U6-gRNA scaffold-EF1-BSD | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 290 | CG102 | pLV-U6-gRNA scaffold-EF1-PURO | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
| 291 | CG103 | pLV-U6-gRNA scaffold-EF1-NEO | 10 μg at 0.5 μg/μL in TE | $751.00 | Add to Cart |
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