Description:

Lentivirus vector based on the human immunodeficiency virus-1 (HIV-1) has become a promising vector for gene transfer studies. Lentiviral vectors packaged as lentiviral particles is one of the most efficient tools to deliver exogenous genes into virtually any types of mammalian cells both in vitro and in vivo, and their use is now commonplace in academic laboratories and industry for both research and clinical gene therapy applications. The advantageous feature of lentivirus vector is the ability of gene transfer and integration into both dividing and non-dividing cells, with low immune response and toxicity in vivo. These viruses also integrate stably into the host genome, enabling long-term transgene expression. Hence, the number of applications to introduce gene product using lentiviruses for in vitro systems, animal models and in clinical trials has been increasing worldwide.

Our third generation lentiviral systems have been designed for increased researcher safety. pLenti-CAG-Luciferase-EF1-NeoR Lentiviral Reporter Vector contains the firefly luciferase gene driven by CAG promoter and NeoR driven by EF1a promoter. The luciferase is widely used as a reporter for studying gene regulation and function, and for pharmaceutical screening. The EF1- NeoR cassette permits G418 selection

Specifications: