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Human iPS Cells (Inducible Ngn2, ApoE4)
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Highlights
ALSTEM offers human iPS cell line with inducible expression of Ngn2 by doxycycline (Dox). This cell line is generated from pre-made footprint-free human iPS cells (cat# iPS16, ApoE4 isoform) with the inducible Ngn2 that has been stably integrated into the human AAVS1 “Safe Harbor” site. It provides a convenient means to differentiate human iPS cells to excitatory neurons rapidly and efficiently. The integration at “Safe Harbor” sites ensures safe and reliable expression of Ngn2 when Dox is supplied.
- Highly responsive doxycycline inducible iPS cell line
- Ideal for rapid in vitro neuronal differentiation
- Especially useful for studying ApoE variants and their roles in neurologic diseases
Neurogenin (Ngn) 2 is a basic helix-loop-helix (bHLH) transcription factor that promotes direct differentiation of pluripotent stem cells to functional excitatory neurons. ALSTEM’s highly responsive doxycycline inducible Ngn2-expressing ApoE4 cell line (cat# iP16NA) is produced from pre-made footprint-free human iPS cells (Cat# iPS16) by integrating an all-in-one inducible Ngn2 cassette into the human AAVS1 “Safe Harbor” site, which supports robust and sustained expression of the inserted gene and allows for rapid neuronal differentiation upon induction.
| Product Name | Human iPS Cells (Inducible Ngn2, ApoE4) |
|---|---|
| Shipping Condition |
Dry Ice - Overnight Shipping |
| Storage and Stability |
Store in the vapor phase of liquid nitrogen immediately upon receipt. This product is stable for 6 months when stored as directed. |
| Quality Control | Human iPS Cells (Inducible Ngn2, ApoE4) were grown in feeder-free conditions with mTeSR1 medium. Each lot of hiPSCs is tested for growth and viability following recovery from cryopreservation. In addition, each lot is tested for expression of TRA-1-60 and OCT4. |
| Restricted Use |
For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
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